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CarboMAX - Enhanced Peptide Coupling at Elevated Temperatures
Introduction
It has been recently shown that rapid and efficient peptide couplings can be performed by in-situ carbodiimide activation at 90°C using a high efficiency solid phase peptide synthesis process (HE-SPPS). HE-SPPS eliminates large amounts of strong base present with onium salt based methods such as HCTU and HATU which lead to significant epimerization (particularly cysteine) and arginine deletions from d-lactam formation. CarboMAX coupling methodology offers further improvements to carbodiimide based methodology through two major improvements.