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cGMP Peptide Production Seminar

November 21, 2018

You're invited to the CEM luncheon seminar at the 10th International Peptide Symposium on December 5th!


Peptide therapeutics are an attractive alternative to their small molecule drug counterparts.1 With several high revenue peptide drugs on the market and a pipeline full of potential candidates2, the demand for highly robust and efficient synthetic methods is of great importance. Microwave assisted SPPS has established itself as the primary chemical method to produce high quality peptides while drastically reducing synthesis time and waste.3 This workshop will highlight new standardized chemistry and technology that encompasses GMP peptide production from mg to kg scale. To validate this comprehensive and simple strategy that utilizes microwave heating and rapid automation, a variety of peptides from current literature were synthesized. Key features of this methodology include:

  • Increased purity and suppressed side reactions such as epimerization as compared to conventional methods
  • Robust, simple synthetic parameters for both standard and non-standard (cyclic, branched, stapled, etc.) sequences
  • One-pot coupling and deprotection process for increased efficiency
  • Reduction of up to 95% generated waste compared to conventional methods

Rapid scale-up for clinical trials and peptide production has been accomplished using similar technology with a focus on elevated temperatures. Crude purity from R&D to production scale is preserved if not improved and unwanted side reactions such as epimerization and aspartimide formation are easily controlled. The result, easier purification and reduced labor cost. Cycle times at the production scale range from 10 – 60 min with the capability to produce up to 1 kg crude peptide in a single batch. Several examples, including process development, will be presented.



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[1] D. J. Craik, D. P. Fairlie, S. Liras, D. Price, Chem Biol Drug Des 81, 136 (2013).
[2] K. Fosgerau, T. Hoffman, Drug Discov Today 20, 122 (2015).
[3] J. M. Collins, K. A. Porter, S. K. Singh, G. S. Vanier, Org. Lett. 16, 940 (2014)