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Reaction Optimization Using a Microwave Autosampler

December 21, 2016
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This Explorer 48-72-96 AppNote features a Hantzsch dihydropyridine synthesis performed in the Discover SP with the Explorer 48 autosampler.  This multi-step reaction is shown to be easily optimized for the microwave through the use of the Explorer autosampler, increasing reaction times and decreasing labor time compared to tedious manual synthesis.