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SPPS Chemicals

Fmoc Amino Acids

CEM offers a variety of high quality natural and non-natural Fmoc amino acids for peptide synthesis. Each amino acid passes through a rigorous quality control process including their use in the synthesis of peptides to qualify reactant performance.
  • Bulk 100 g and 1 kg quantities of natural Fmoc amino acids
  • Pre-weighed 2.5 and 5.0 mmol tubes for use on the Liberty Blue
  • Amino acids for preventing aspartimide
  • Phosphoamino acids
Shop Fmoc Amino Acids

ProTide® SPPS Resin

Ultimate SPPS resin featuring a PEG and polystyrene core, an ideal synthetic environment for high purity peptides. ProTide can furnish peptide amides or acids using novel, universal loading linkers .

ProTide Resin Products

Acid linkers Amide linker
Cl-TCP(Cl)
0.30 - 0.50 mmol/g loading
Rink Amide
0.60 – 0.80 mmol/g loading
Cl-TCP(Cl) Low Loading (LL)
0.15 - 0.25 mmol/g loading
Rink Amide Low Loading (LL)
0.15 – 0.25 mmol/g loading
Cl-MPA Low Loading (LL)
0.15 - 0.25 mmol/g loading
Shop ProTide Resins

Activators

Oxyma Pure used with DIC produces peptides with increased yield and decreased epimerization when used as an alternative to HOBt1 . This safe, non-explosive auxiliary nucleophile works with carbodiimide coupling strategies to provide the best results for a peptide synthesis. Additionally, the use of DIC/Oxyma avoids side reactions associated with high levels of base (≥ 1 equiv. DIEA) using onium salt methods such as HBTU/DIEA.


1 R. Subirós-Funosas, et al. (2009) Chem. Eur. J., 15, 9394. Shop Activators

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  1. Fmoc-Ala-OH

    Fmoc-Ala-OH

    Part #: A001
    Starting at $45

    N-Fmoc-alanine Learn More
  2. Fmoc-His(Trt)-OH

    Fmoc-His(Trt)-OH

    Part #: A009
    Starting at $75

    Nα-Fmoc-Nt-trityl-histidine Learn More
  3. Fmoc-Lys(Boc)-OH

    Fmoc-Lys(Boc)-OH

    Part #: A012
    Starting at $75

    Nα-Fmoc-Nξ-Boc-lysine Learn More
  4. Fmoc-Ser(tBu)-OH

    Fmoc-Ser(tBu)-OH

    Part #: A016
    Starting at $75

    N-Fmoc-O-tert-butyl-serine Learn More
  5. Fmoc-Thr(tBu)-OH

    Fmoc-Thr(tBu)-OH

    Part #: A017
    Starting at $75

    N-Fmoc-O-tert-butyl-threonine Learn More
  6. Fmoc-Tyr(tBu)-OH

    Fmoc-Tyr(tBu)-OH

    Part #: A019
    Starting at $75

    N-Fmoc-O-tert-butyl-tyrosine Learn More
  7. Fmoc-Arg(Pbf)-OH

    Fmoc-Arg(Pbf)-OH

    Part #: A002
    Starting at $125

    Nα-Fmoc-Nω-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-arginine Learn More
  8. Fmoc-Trp(Boc)-OH

    Fmoc-Trp(Boc)-OH

    Part #: A018
    Starting at $100

    Nα-Fmoc-N(in)-Boc-tryptophan Learn More
  9. Rink Amide ProTide Resin

    Rink Amide ProTide Resin

    Part #: R003
    Starting at $50

    A powerful resin recommended for the synthesis of peptides with amide linkages < 30 amino acids. Based on ideal swelling properties from incorporating a PEG PS core with a loading of 0.55 - 0.8 mmol/g. Learn More
  10. Cl-TCP(Cl) ProTide Resin

    Cl-TCP(Cl) ProTide Resin

    Part #: R005
    Starting at $95

    A powerful resin recommended for the synthesis of peptides with acid linkages < 30 amino acids. Based on ideal swelling properties from incorporating a PEG PS core with a loading of 0.4 - 0.6 mmol/g. This resin features an activated chloride linker, allowing for attachment of the first amino acid in an unactivated form. This resin is recommended for protection of c-terminal cysteine and proline residues due to its steric protection against diketopiperazine formation and 3-(1-Piperidinyl) alanine formation. Learn More

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