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CoolMate

 

CEM CoolMate Sub-ambient Synthesis
Experience the benefits of microwave-enhanced reaction rates in a system designed for sub-ambient temperature synthesis!
  • Explore new pathways in temperature-sensitive reactions
  • Ideal for highly reactive species
Now, you can perform low-temperature reactions in a microwave synthesis system and still achieve the same rate enhancements commonly associated with high-temperature reactions. Perform any temperature-sensitive reactions including carbohydrate chemistry, eliminations, substitutions, formation of carbanions and other highly reactive intermediates.
  • Integrated cooling system assures the lowest temperature range possible with any microwave system
  • Jacketed vessel design with removable reaction vials for convenience and easy set up
  • Exclusive microwave-transparent cooling media
  • Work with reaction volumes from 250 µL to 7 mL
  • In situ fiber optic temperature monitoring
  • Onboard reaction monitoring provides feedback for unattended operation
  • Compact design fits in a fume hood
Designed using the versatile Discover® platform, CoolMate offers all of the ease-of-use and flexibility for which CEM Chemical Synthesis systems are known.


How CoolMate Works



Discover CoolMate gives chemists access to new pathways in temperature-sensitive reactions, some of which cannot be produced under conventional conditions.

Because microwave energy is transferred kinetically, not thermally, microwaves can accelerate reactions maintained at low temperatures. CoolMate's proprietary jacketed reaction vessel and exclusive cooling media are both microwave transparent, insuring the full energy transmission directly to your reactants.

The vessel and cooling technology keep the bulk temperature of the reactants low, preventing thermal degradation of the product. An in situ fiber optic probe ensures fast, accurate temperature measurement.




CoolMate Chemistries

Sub-ambient microwave synthesis is most effective for reactions that are temperature sensitive or those that are slow to proceed, as in the following examples.

The cis isomer is the desired product in the substitution reaction between the cis-1,4-dichloro-2-butene and a phenoxide anion in Figure 1. Conventionally, this reaction takes 21 hours. It is held for 6 hours at 0°C, then it is allowed to warm to 20°C and react for an additional 15 hours.

Using CoolMate, the reaction was accelerated by allowing it to proceed for 35 minutes at 30°C. The microwave procedure achieved an 87% yield, compared to a 75% yield conventionally. The formation of the cis isomer was confirmed.







Figure 1. Diphenoxybutene Synthesis.
Roversi, E.; Monnat, F.; Vogel, P.; Helv. Chim. Acta, 2002, 85, 733.

Elimination reactions catalyzed by n-butyllithium typically necessitate room temperature, or lower, reaction conditions. Previously, these temperature limits prevented its use in a microwave. The reaction shown in Figure 2 illustrates how a reactive species, such as n-butyllithium, can be utilized in a microwave. To achieve a 78% yield conventionally, the reaction took 2.5 hours, ranging in temperature from 0 °C to 25 °C. Because the transfer of energy in a microwave is dependent on kinetic transfers and not on thermal energy, the transformation could be accomplished at -60 °C in 5 minutes with a yield of 81%.







Figure 13. Phenoxydiene Synthesis.
Roversi, E.; Monnat, F.; Vogel, P.; Helv. Chim. Acta, 2002, 85, 733.

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  1. CoolMate Sub-Ambient Temperature Module for Discover SP or Discover S-Class

    CoolMate Sub-Ambient Temperature Module for Discover SP or Discover S-Class

    Part #: 925582

    Discover system accessory for reactions with sub-ambient temperatures as low as -80°C.

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