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Flow Cells

Microwave chemistry has long been known to accelerate chemical transformations and provide a simple means to access more rigorous reaction conditions. Flow chemistry has demonstrated similar benefits, with the added bonus of being able to increase the reaction scale simply by prolonging the reaction. The combination of the two technologies opens the door to a quick optimization and easy scale-up of virtually unlimited types of chemical transformations. The Discover® SP System provides the means to perform both types of reactions simultaneously or sequentially within the same system. Use of microwave heating allowed access to a temperature of 190 °C, well above the boiling point of acetonitrile. This increased temperature resulted in a pressure of nearly 200 psi during the batch reaction. Despite these forcing conditions, the reaction proved suitable for synthesis in flow, providing a modest increase in yield with a 20-fold increase in scale.

Discover 10-mL and 80-mL Flow Cells

10-mL and 80-mL Flow Cells

Explore continuous flow chemistry in the microwave using two standard flow cell sizes.

MAX. TEMPERATURE: 300 °C
MAX. PRESSURE: 18 bar (250 psi)

View Flow TechNote

Table 1: Heck Reagents Required

Reagent Batch Flow
Iodobenzene 0.101 g 2.02 g
Butyl acrylate 0.127 g 2.54 g
Pd(OAc)2 0.06 mg 1.2 mg
DIPEA 0.096 g 1.92 mg
MeCN 1 mL 20 mL

Table 2: Heck Coupling Conditions

Mode Temperature Time Scale Isolated Yield
Batch 190 °C 5 minutes 0.5 mmol 89%
Flow 190 °C 30 minutes 10 mmol 91%

Set Descending Direction

17 Item(s)

  1. 1/8" Yellow Ferrule

    1/8" Yellow Ferrule

    Part #: 164315

    The 1/8" Yellow Ferrule is used to secure 1/8" OD tubing. Learn More
  2. 164810

    Rare Earth Stir Bar

    Part #: 164810

    9 mm x 15 mm stir bar, used with all 80 mL reaction vessel accessories. Learn More
  3. 163456

    Multibit Reversible Screwdriver

    Part #: 163456

    Multibit Reversible Screwdriver Learn More
  4. 164920

    Discover 80 mL Lifter Cup

    Part #: 164920

    Discover 80 mL attenuator vessel lifter cup. Learn More
  5. 164305

    PFA Tubing, 1/8" OD 1/16" ID

    Part #: 164305

    PFA Tubing, 1/8" OD 1/16" ID Learn More
  6. 165995

    Pressure Tube Fitting with Ferrule, 3.65" Extension

    Part #: 165995

    Pressure tube fitting with ferrule and 3.65" extended tube for the 10 mL Discover flow cell. Learn More
  7. 165990

    Pressure Tube Fitting with Ferrule, 0.25" Extension

    Part #: 165990

    Pressure tube fitting with ferrule and 0.25" extended tube for the 10 mL Discover flow cell. Learn More
  8. Tube Fitting, 5/16-24 for 1/8" Tube

    Tube Fitting, 5/16-24 for 1/8" Tube

    Part #: 165180

    Tube fitting, 5/16-24 for 1/8" tube for the 10 mL Discover flow cell. Learn More
  9. 544620

    10 mL Flow Cell Top

    Part #: 544620

    10 mL flow cell vessel top for the Discover S-Class and Discover SP. Learn More
  10. 544610

    10 mL Flow Cell Attenuator

    Part #: 544610

    10 mL flow cell attenuator for the Discover S-Class and Discover SP. Not compatible with the Discover Legacy. Learn More
  11. Flangeless Nut, 1/4-28 x 1/8"

    Flangeless Nut, 1/4-28 x 1/8"

    Part #: 164545

    Replacement long flangeless nut, 1/4-28 x 1/8" for the 10 mL and 80 mL flow cells. Learn More
  12. Flow Cell Dip Tube

    Flow Cell Dip Tube

    Part #: 164307

    Dip tube replacement for the 80 mL flow cell. Learn More
  13. 80 mL Flow Cell Locking Cover

    80 mL Flow Cell Locking Cover

    Part #: 542380

    Locking cover assembly for the Discover SP 80 mL flow cell. Learn More
  14. 164755

    Fitting Removal Tool

    Part #: 164755

    1" (2.54 cm) fitting removal tool. Learn More
  15. 165010

    80 mL Vessel Holder

    Part #: 165010

    Vessel stand for the 80 mL Discover vessel. Learn More
  16. 165034

    80 mL Reaction Vessel

    Part #: 165034

    The 80 mL reaction vessel has a maximum working volume of 50 mL and miniumum working volume of 15 mL. This vessel can also withstand temperatures up to 200°C with the IR (250°C with fiber optic) and pressure up to 200 psi (250 psi with fiber optic).

    Learn More
  17. 173945

    Phillips Head Screwdriver

    Part #: 173945

    Phillips head screwdriver Learn More