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Flow Cells

Microwave chemistry has long been known to accelerate chemical transformations and provide a simple means to access more rigorous reaction conditions. Flow chemistry has demonstrated similar benefits, with the added bonus of being able to increase the reaction scale simply by prolonging the reaction. The combination of the two technologies opens the door to a quick optimization and easy scale-up of virtually unlimited types of chemical transformations. The Discover® SP System provides the means to perform both types of reactions simultaneously or sequentially within the same system. Use of microwave heating allowed access to a temperature of 190 °C, well above the boiling point of acetonitrile. This increased temperature resulted in a pressure of nearly 200 psi during the batch reaction. Despite these forcing conditions, the reaction proved suitable for synthesis in flow, providing a modest increase in yield with a 20-fold increase in scale.

Discover 10-mL and 80-mL Flow Cells

10-mL and 80-mL Flow Cells

Explore continuous flow chemistry in the microwave using two standard flow cell sizes.

MAX. TEMPERATURE: 300 °C
MAX. PRESSURE: 18 bar (250 psi)

View Flow TechNote

Table 1: Heck Reagents Required

Reagent Batch Flow
Iodobenzene 0.101 g 2.02 g
Butyl acrylate 0.127 g 2.54 g
Pd(OAc)2 0.06 mg 1.2 mg
DIPEA 0.096 g 1.92 mg
MeCN 1 mL 20 mL

Table 2: Heck Coupling Conditions

Mode Temperature Time Scale Isolated Yield
Batch 190 °C 5 minutes 0.5 mmol 89%
Flow 190 °C 30 minutes 10 mmol 91%

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  1. 1/8" Yellow Ferrule

    1/8" Yellow Ferrule

    Part #: 164315

    The 1/8" Yellow Ferrule is used to secure 1/8" OD tubing. Learn More
  2. 164810

    Rare Earth Stir Bar

    Part #: 164810

    9 mm x 15 mm stir bar, used with all 80 mL reaction vessel accessories. Learn More
  3. 163456

    Multibit Reversible Screwdriver

    Part #: 163456

    Multibit Reversible Screwdriver Learn More
  4. 164920

    Discover 80 mL Lifter Cup

    Part #: 164920

    Discover 80 mL attenuator vessel lifter cup. Learn More
  5. 164305

    PFA Tubing, 1/8" OD 1/16" ID

    Part #: 164305

    PFA Tubing, 1/8" OD 1/16" ID Learn More
  6. 165995

    Pressure Tube Fitting with Ferrule, 3.65" Extension

    Part #: 165995

    Pressure tube fitting with ferrule and 3.65" extended tube for the 10 mL Discover flow cell. Learn More
  7. 165990

    Pressure Tube Fitting with Ferrule, 0.25" Extension

    Part #: 165990

    Pressure tube fitting with ferrule and 0.25" extended tube for the 10 mL Discover flow cell. Learn More
  8. Tube Fitting, 5/16-24 for 1/8" Tube

    Tube Fitting, 5/16-24 for 1/8" Tube

    Part #: 165180

    Tube fitting, 5/16-24 for 1/8" tube for the 10 mL Discover flow cell. Learn More
  9. 544620

    10 mL Flow Cell Top

    Part #: 544620

    10 mL flow cell vessel top for the Discover S-Class and Discover SP. Learn More
  10. 544610

    10 mL Flow Cell Attenuator

    Part #: 544610

    10 mL flow cell attenuator for the Discover S-Class and Discover SP. Not compatible with the Discover Legacy. Learn More

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