Greening Peptide Purification Through Replacement of Acetonitrile with Ethanol

The global demand for peptide therapeutics is rapidly increasing, placing new emphasis on improving both the efficiency and sustainability of peptide production. One key area of focus is the development of greener alternatives to traditional solvents like acetonitrile for purification processes.

Ethanol has emerged as a promising alternative due to its low UV cutoff and comparable separation performance. However, its higher viscosity has historically limited its routine use, especially with fine particle size columns.

In this webinar, we will explore how elevated temperature conditions, enabled by a novel integrated heating system, can overcome these limitations. Attendees will learn how this approach allows the routine use of ethanol-based mobile phases, even with 5 µm particle size columns, improving both workflow efficiency and sustainability.

Join us to discover how this innovative approach can transform your peptide purification workflows.