Automated Deprotection of Orthogonal and Non-Standard Lysine Protecting Groups

Introduction

Peptidyl side-chain functionalizations, such as bioconjugation, branching, and cyclization, are impactful and essential synthetic tools, necessary for pharmaceutical development, medical imaging, materials research, and more. Many amino acid residues can serve as sites for side-chain functionalization; lysine, however, has received particular attention.