CarboMAX - Enhanced Peptide Coupling at Elevated Temperatures
CarboMAX™ is a new patented coupling methodology for peptide synthesis at elevated temperature. It offers improvements over existing carbodiimide methodology by providing faster activation and corresponding reduction in epimerization. Additionally, it offers increased stabilization of acid sensitive linkages at high temperature which is particularly beneficial for phosphopeptides, glycopeptides, and synthesis of peptides on hyper-acid sensitive linkers. This was demonstrated on the synthesis of 8 well-known peptides synthesized using standard carbodiimide chemistry versus CarboMAX methodology on the Liberty Blue automated peptide synthesizer.