Automated Microwave Peptide Synthesizer
Liberty Blue

Synthesize peptides more efficiently than ever before.


The Liberty Blue™ Automated Microwave Peptide Synthesizer is the best selling peptide synthesizer in the world. It features a 4-minute cycle time along with a 90% solvent reduction based on High Efficiency Solid Phase Peptide synthesis (HE-SPPS) developed in 2013. This system is utilized in hundreds of laboratories worldwide and provides unparalleled peptide quality based on its unique methodology and use of microwave energy. The Liberty Blue features the latest in engineering for fluidic deliveries, true internal temperature feedback control, and software control with 21 CFR Part 11 compliance.

2014 R&D 100 Award Winner

Unique Chemistry

  • CarboMAX™ coupling chemistry (patented)
  • Microwave deprotection and coupling (patented)


  • 4 min cycle time
  • 90% waste reduction (HE-SPPS)
  • Flex-Add™ critical reagent delivery system (patented)
  • True Internal fiber-optic temperature control
  • 0.005 - 5 mmol scale range
  • 27 amino acid positions
  • Integrated Camera (optional)
  • High-throughput upgrade options

Peptide Synthesizer Speed


An Incredibly Fast Peptide Synthesizer

  • 4 min cycle times (HE-SPPS)
  • Access to peptides in less than a day
  • Optional automated synthesis of up to 24 peptides
CarboMAX coupling for peptide synthesis


The best coupling method for peptide synthesis

  • The fastest and most complete coupling
  • Unmatched low level of epimerization for all 20 amino acids
  • Highest purities with patented microwave deprotection and coupling (US7393920, US7582728, US8058393, CA2471687)
  • Simplify synthesis by eliminating the need for time consuming method screening

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Peptide Synthesizer Reagent Delivery - Flex Add


The best way to deliver critical reagents

  • Infinitely variable – deliver whatever volume you want (unlike sample loops)
  • No priming ever
  • No washing and less complex than syringe pumps
Peptide Synthesizer Solvent Waste

Solvent Reduction

Unprecedented 90% solvent reduction

  • Judicious use of solvents and reagents from optimized washing and synthetic protocols
  • Superior system design minimizes calibration, cleaning, and maintenance needs
Peptide Synthesizer Software


The most advanced software for simple and flexible control

  • Automated programming of standard and complex peptides (branched, cyclized, disulfide bonding)
  • 21 CFR Part 11 compliance including full run history and method reports
  • Integrated real-time camera into microwave cavity
Peptide Synthesizer Crude Purity


We’ve raised the standard for peptide purity

Liberty Blue systems deliver unparalleled peptide quality and synthesis success. From the fundamental principle of using controlled microwave energy to heat the reaction and not the vessel, to the innovative design of hardware, software and specialty chemicals, to the focus on efficient systems for loading, delivery, monitoring and removal, everything contributes to optimal chemistry for the highest purity and yields.

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Synthesize Phosphopeptides, Glycopeptides, Branched Peptides, PNA, Peptoids and More


Synthesize standard and complex peptides

  • Branched Peptides
  • Cyclized Peptides
  • Disulfide Bonding
  • Glycopeptides (N/O-linked)
  • High Throughput Synthesis
  • N-Methyl Peptides
  • Peptide Thioesters
  • Peptoids
  • Phospho-peptides
  • PNA

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November 10, 2015

101mer Proteins with Liberty Blue

Prof. Fernando Albericio
University of Barcelona

July 29, 2015

Peptide Institute Gains Overwhelming ...

Dr. Hajime Hibino
Peptide Institute

July 7, 2015

A New Weapon Against HIV: ...

Dr. Adel Ahmed
Drexel University

May 12, 2015

Disulfide Bonding: Improvements ...

Dr. Olga Avrutina
Technische Universität Darmstadt

April 20, 2015

PeptiDream Invests in Liberty Blue

Dr. Patrick C. Reid
PeptiDream Inc.

March 30, 2015

New Methods for Protein Synthesis

Prof. Hironobu Hojo
Osaka University

June 28, 2015

New Insights Toward α-Synuclein: ...

Dr. Jody Mason
University of Bath

June 4, 2015

Liberty Blue Shines at PeptLab

Prof. Anna Maria Papini>
University of Florence.

May 24, 2015

Hyper-Stable β-Sheets ‚ Amphipathic ...

Dr. Brandon Kier
University of Washington