SPPS Resins

CEM - Resins - High quality resins for solid
phase peptide synthesis.
Overview

High quality resins for solid phase peptide synthesis.

Overview

Further resin and linker selection can improve a synthesis, particularly in the case of a challenging peptide synthesis. Sterically bulky linkers like the Cl-TCP(Cl) or 2-chlorotrityl linker show suppression of side reactions like diketopiperazine and piperidinyl alanine formation.1 The completed peptide and side chain protecting groups can be cleaved from the resin using concentrated trifluoroacetic acid (TFA) for most peptide linkers. Hyperacid sensitive linkers, such as Cl-TCP(Cl) or 2-chlorotrityl can be cleaved with dilute TFA (<1%) to furnish a free, solution phase peptide with side chain protection, intact for convenient post-synthetic modifications. The Cl-TCP(Cl) linker improves upon the standard 2-chlorotrityl with improved stability at elevated temperature without sacrificing hyper acid sensitivity.


Products

resins protide Image

ProTide Resins

For Very Long and Difficult Peptides



Based on a PEG-PS core with optimal swelling, recommended for synthesis of very long and difficult peptides.


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resins polystryrene image

Polystyrene Resins

Affordable and Easy to Use



High quality preloaded polystyrene resins for synthesis of standard and difficult peptides.


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1. D’Hondt, M.; Bracke, N.; Taevernier, L.; Gevaert, B.; Verbeke, F.; Wynendaele, E.; De Spiegeleer, B. Drug Quality and Registration (DruQuaR) Group, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, B-9000 Ghent, Belgium. Related Impurities in Peptide Medicines. Journal of Pharmaceutical and Biomedical Analysis. [Online] 2014, Vol. 101, pp 2-30. link (accessed July 20, 2021).