Webinar: Massive Waste Reduction in the Synthesis and Purification of Challenging Peptides

The growing demand for synthetic peptides in research calls for efficient, automated synthesizers. Synthetic peptides are vital tools for a wide range of biochemical experiments.

Traditional solid-phase peptide synthesis (SPPS, Merrifield method) relies heavily on the solvent DMF. However, under EU Regulation 2021/2030, DMF usage will be significantly restricted, prompting a shift to greener alternatives.

CEM’s Liberty Blue microwave peptide synthesizers are compatible with alternative “green” solvents like TamiSolve (N-butylpyrrolidinone, NBP). Despite being more viscous than DMF, TamiSolve achieves comparable synthesis results on the Liberty Blue 2.0 and Liberty Prime 2.0 platforms.

A major innovation, the “No Wash” SPPS strategy (Nature Com., December 2023), minimizes solvent usage by eliminating all washing steps in the peptide bond formation cycle. A key breakthrough is the evaporation of the volatile base used for Fmoc deprotection at elevated temperatures, reducing waste without affecting product quality. This approach has been successfully applied to a variety of challenging sequences, including peptides up to 89 amino acids long, at both research and production scales.

In this free online seminar on January 27th, 2026, at 10 a.m. and 2 p.m., Dr. Hohn-Hein and Dr. Technau will present this innovative synthesis strategy. The seminar will be held in English.

This webinar will be offered at 10 AM CET in German and 2 PM CET in English