Automated Synthesis of Cyclic Disulfide-Bridged Peptides

Introduction

Cyclic peptides containing disulfides represent a class of compounds with a profound array of biological functions ranging from venoms to integral hormones. The disulfide bond helps stabilize the secondary structure and conformation of peptides, which can contribute favorably to proteolytic stability and target affinity. Because of their promising therapeutic potential, interest in the synthesis of cyclic disulfide-bridged peptides has grown steadily.