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Microwave Peptide Synthesizer
Liberty PRIME 2.0
Microwave Peptide Synthesizer
Liberty PRIME 2.0
Overview
The Liberty PRIME™ 2.0 is the absolute best peptide synthesizer available in the world. The system features a unique one-pot deprotection and coupling process allowing for a remarkable 2 minute cycle time with only 8.5mL waste per cycle (at 0.1mmol). A key improvement in the 2.0 version of the Liberty PRIME is the ability to make cleaner and longer peptides with a new level of robustness than previously possible.The Liberty PRIME 2.0 provides the ultimate flexibility for long, difficult, or complex peptides. Additionally, the system provides ultra-fast sequential synthesis workflow that can dramatically outperform traditional parallel peptide synthesizers. The Liberty PRIME 2.0 can be utilized in cGMP peptide production.
Features
- Unprecedented 2.5 min cycle time (at 0.1mmol)
- Unrivaled 8.5mL waste per cycle (at 0.1mmol)
- Precise calibration-free delivery of all reagents
- True Internal fiber-optic temperature control
- 0.005 - 5 mmol scale range w/ digital N2 control
- 30 amino acid positions
- Integrated RV Camera
- High-throughput upgrade options (HT4, HT12, HT24)
- Ability to use in cGMP peptide production
Unmatched Quality
A new level of peptide purity.
The Liberty PRIME 2.0 provides the ability to make even higher purity peptides than previously possible with the original Liberty Blue system. This is based on advances in the system fluidics, reaction vessel environment, and chemistry methodology.
- Optimized microwave chemistry methodology with ProTide resins
- Cleanest reaction environment with updated headspace flushing technology
- More direct optimized flow paths
- Digitally variable N2 control for optimized bubbling, purging, and draining
View application data
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BarstarLength: 89 amino acidsSynthesis Time: 11 h 26 min Waste Generated: 1660 mL Scale: 0.05 mmol View chromatogram |
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HIV ProteaseLength: 99 amino acidsSynthesis Time: 12 hrs. 48 min. Waste Generated: 1829 mL Scale: 0.05 mmol View chromatogram |
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MDM2Length: 127 amino acidsSynthesis Time: 16 hrs. 26 min. Waste Generated: 2316 mL Scale: 0.05 mmol View chromatogram |
Unrivaled Speed
Synthesize 20mer’s every 45 minutes.
Based on a revolutionary one-pot deprotection and coupling process, along with the patented CarboMAX coupling chemistry, an unprecedented 2 minute cycle time is achieved.View application data
Solvent
Reduce SPPS chemical waste to unbelievable levels.
By using a patented process that reuses the coupling solution for the subsequent deprotection step, along with a system design that requires no internal washing the Liberty PRIME 2.0 reduces waste to unimaginable levels.
Up to 50% Less Waste
The Liberty PRIME 2.0 produces significantly less waste than the highly efficient Liberty Blue 2.0!
Advanced Reagent Delivery System
No calibration is needed.
All reagents are delivered either by pressure-based Flex-Add delivery system or precalibrated pumping system.
This means you can always be confident that the right amount of each reagent is delivered every time at volumes as low as 0.25mL. The Liberty PRIME 2.0 provides calibration-free reagent delivery that is ideal for cGMP processes.
CarboMAX
The best coupling method for peptide synthesis.
- The fastest and most complete coupling
- Stabilizes acid sensitive linkages which are problematic for standard carbodiimide chemistry (phospho, glyco, hyper-acid linkages)
- Unmatched low-level of epimerization for all 20 amino acids due to faster activation (faster o-acylisourea formation)
View application data
High Throughput (HT) Loaders
High-throughput peptide synthesis made easy.
- Automated synthesis of 4, 12, or 24 peptides (individual 20mer’s can be completed every hour)
- The Liberty PRIME 2.0 paired with either the HT4, HT12, or HT24 outperforms conventional parallel systems
View application data
Software
Flexible, Powerful Software
Easy and Flexible Sequence Programming
The method editor on the Liberty PRIME 2.0 allows full customization of reaction parameters.
Program Post-Synthesis Modification
Versatile options enabling orthogonal deprotection for modifications like branching and cyclization.
Full Suite of Calculator Tools
Convenient calculators provide the reagents and amounts for a run.
Pause, Edit, Monitor at any Step
Easily pause, edit, and monitor reactions from the run screen.
Audit Trail
Equipped with audit trail, the Liberty Prime 2.0 software time/date stamps all changes, runs, maintenance operations, etc.
21 CFR Part 11 Compliant
The Liberty Prime 2.0 software is 21 CFR part 11 compliant, ready for cGMP laboratory environments.
Applications
Synthesize standard and complex peptides.
The Liberty 2.0 series, like preceding models, utilizes CEM’s High-Efficiency Solid Phase Peptide Synthesis (HE-SPPS) and CarboMAX coupling methodologies,| Branched Peptides | High Throughput Synthesis |
| Cyclized Peptides | N-Methyl Peptides |
| Disulfide Bonding | Peptoids |
| Glycopeptides (N/O-linked) | Phosphopeptides |
