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Microwave Peptide Synthesizer
Liberty Blue 2.0
Microwave Peptide Synthesizer
Liberty Blue 2.0
Synthesize peptides efficiently for research and development.
The Liberty Blue™ 2.0 is an ultra-efficient microwave peptide synthesizer, delivering high-quality peptides with record low waste generation and synthesis times. Through partnering CEM's patented and published No-Wash methodology with flexible and intuitive system controls, the Liberty Blue 2.0 opens up a world of more efficient, high-yielding, and structurally complex syntheses than ever thought possible.- <4 minutes per amino acid (AA) addition (includes coupling through deprotection, scales under 0.5 mmol)
- <6 mL waste generated per AA addition (includes coupling through deprotection, scales under 0.2 mmol )
- 0.005 to 5 mmol synthesis scale range
- HT accessories available for queueing up to 12 syntheses
- 21CFR Part 11 compliant software
Ultra Efficient - Solid Phase Peptide Synthesis (UE-SPPS)
New "No Wash" approach, same clean peptides.
With this Liberty system comes the revolutionary UE-SPPS methodology; total wash elimination. Through a remarkable combination of methodology optimization, reagent selection, and engineering advancements, CEM's "No Wash" technology reduces waste production by up to 95%, and all without sacrificing synthesis yield and purity.Learn more about UE-SPPS
Semaglutide (Crude)
Length: 31 Amino AcidsScale: 0.1 mmol
Synthesis Time: ~ 1 hour, 50 minutes
Waste: 135 mL (Liberty PRIME 2.0) or 238 mL (Liberty Blue 2.0)
1-42β-amyloid (Crude)
Length: 42 Amino AcidsScale: 0.1 mmol
Synthesis Time: ~ 2 hours, 30 minutes
Waste: 179 mL (Liberty PRIME 2.0) or 316 mL (Liberty Blue 2.0)
Proinsulin (Crude)
Length: 86 Amino AcidsScale: 0.1 mmol
Synthesis Time: ~ 10 hours, 40 minutes
Waste: 687 mL (Liberty PRIME 2.0) or 973 mL (Liberty Blue 2.0)
Unmatched Peptide Quality
A new level of peptide purity.
With advancements in system fluidics, reaction vessel environment, and chemistry methodology achieve better synthesis results than ever before.Better Chemistry
- Carbodiimide coupling strategy for reduced epimerization and side reactions
- ProTide resin development for optimized loading and swelling parameters
- Microwave heating approach for improved reaction efficiency and synthesis results
Better Engineering
- Headspace flushing technology for cleaner reaction environment
- Optimized flow paths for simple and efficient reagent delivery
- Digitally variable N₂ control for enhanced bubbling, purging, and draining
Accurate Reagent Delivery
The best way to deliver critical reagents.
FlexAdd Technology
- No volume constraints for infinitely variable delivery quantities, unlike sample loops
- Never prime - avoid unnecessary consumption of expensive and precious reagents
- No washing for elegant flow path design eliminates waste from background cleaning steps
High Throughput (HT) Loaders
More peptide synthesis, less hands-on time.
- Queue up to 4 sequential syntheses with the optional HT4 accessory, and up to 12 sequential syntheses with the HT12 accessory.
- Each peptide is available immediately, eliminating purification bottlenecks common with batch syntheses.
Software
Flexible, Powerful, Traceable
Specialty Applications
Non-standard peptides? No problem.
- Branched Peptides
- Disulfide Bonding Peptoids
- High Throughput Synthesis
- Phosphopeptides
- Proteins
- Cyclized Peptides
- Glycopeptides (N/O-linked)
- N-Methyl Peptides
- PNAS
- Stapled Peptides
View all application notes
