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Microwave Peptide Synthesizer
Liberty PRIME 2.0
Microwave Peptide Synthesizer
Liberty PRIME 2.0
Synthesize peptides efficiently for high production demands.
The Liberty PRIME™ 2.0 is an ultra-efficient microwave peptide synthesizer, delivering high-quality peptides with record low waste generation and synthesis times. Through partnering CEM's patented and published No-Wash methodology with flexible and intuitive system controls, the Liberty PRIME 2.0 opens up a world of more efficient, high-yielding, and structurally complex syntheses than ever thought possible.- <4 minute per amino acid (AA) addition (includes coupling through deprotection, scales under 0.5 mmol)
- <5 mL waste generated per AA addition (includes coupling through deprotection, scales under 0.2 mmol )
- 0.005 to 5 mmol synthesis scale range
- HT accessories available for queueing up to 24 syntheses
- cGMP peptide production compliant package available
Ultra Efficient - Solid Phase Peptide Synthesis (UE-SPPS)
New "No Wash" approach, same clean peptides.
With this Liberty system comes the revolutionary UE-SPPS methodology; total wash elimination. Through a remarkable combination of methodology optimization, reagent selection, and engineering advancements, CEM's "No Wash" technology reduces waste production by up to 95%, and all without sacrificing synthesis yield and purity.Learn more about UE-SPPS
Semaglutide (Crude)
Length: 31 Amino AcidsScale: 0.1 mmol
Synthesis Time: ~ 1 hour, 50 minutes
Waste: 135 mL (Liberty PRIME 2.0) or 238 mL (Liberty Blue 2.0)
1-42β-amyloid (Crude)
Length: 42 Amino AcidsScale: 0.1 mmol
Synthesis Time: ~ 2 hours, 30 minutes
Waste: 179 mL (Liberty PRIME 2.0) or 316 mL (Liberty Blue 2.0)
Proinsulin (Crude)
Length: 86 Amino AcidsScale: 0.1 mmol
Synthesis Time: ~ 10 hours, 40 minutes
Waste: 687 mL (Liberty PRIME 2.0) or 973 mL (Liberty Blue 2.0)
Unmatched Peptide Quality
A new level of peptide purity.
With advancements in system fluidics, reaction vessel environment, and chemistry methodology achieve better synthesis results than ever before.Better Chemistry
- Carbodiimide coupling strategy for reduced epimerization and side reactions
- ProTide resin development for optimized loading and swelling parameters
- Microwave heating approach for improved reaction efficiency and synthesis results
Better Engineering
- Headspace flushing technology for cleaner reaction environment
- Optimized flow paths for simple and efficient reagent delivery
- Digitally variable N₂ control for enhanced bubbling, purging, and draining
Advanced Reagent Delivery System
The best way to deliver critical reagents.
All reagents are delivered either by pressure-based Flex-Add delivery system or precalibrated pumping system.- No volume constraints for infinitely variable delivery quantities, unlike sample loops
- No calibrations for calibration-free reagent delivery ideal for cGMP processes
- Never prime amino acids - avoid unnecessary consumption of expensive and precious reagents
- No washing for elegant flow path design eliminates waste from background cleaning steps
High Throughput (HT) Loaders
More peptide synthesis, less hands-on time.
Queue up to 4 sequential syntheses with the optional HT4 accessory, up to 12 sequential syntheses with the HT12, and up to 24 sequential syntheses with the HT24.Each peptide is available immediately, eliminating purification bottlenecks common with batch syntheses.
View Application Data
Software
Flexible, Powerful, Traceable
Enter the Parameters
The method editor on the Liberty Blue allows full customization of reaction parameters.Enlarge
Pause, Edit, Monitor at any Step
Easily pause, edit, and monitor reactions from the run screen.Enlarge
21 CFR Part 11 Compliant
The Liberty software is 21 CFR part 11 compliant, ready for cGMP laboratory environments.Enlarge
Specialty Applications
Non-standard peptides? No problem.
- Branched Peptides
- Disulfide Bonding Peptoids
- High Throughput Synthesis
- Phosphopeptides
- Proteins
- Cyclized Peptides
- Glycopeptides (N/O-linked)
- N-Methyl Peptides
- PNAS
- Stapled Peptides
View all application notes
