Flow Cells

Microwave chemistry has long been known to accelerate chemical transformations and provide a simple means to access more rigorous reaction conditions. Flow chemistry has demonstrated similar benefits, with the added bonus of being able to increase the reaction scale simply by prolonging the reaction. The combination of the two technologies opens the door to a quick optimization and easy scale-up of virtually unlimited types of chemical transformations. The Discover® SP System provides the means to perform both types of reactions simultaneously or sequentially within the same system. Use of microwave heating allowed access to a temperature of 190 °C, well above the boiling point of acetonitrile. This increased temperature resulted in a pressure of nearly 200 psi during the batch reaction. Despite these forcing conditions, the reaction proved suitable for synthesis in flow, providing a modest increase in yield with a 20-fold increase in scale.

Discover 10-mL and 80-mL Flow Cells

10-mL and 80-mL Flow Cells

Explore continuous flow chemistry in the microwave using two standard flow cell sizes.

MAX. TEMPERATURE: 300 °C
MAX. PRESSURE: 18 bar (250 psi)

View Flow TechNote

Table 1: Heck Reagents Required

Reagent Batch Flow
Iodobenzene 0.101 g 2.02 g
Butyl acrylate 0.127 g 2.54 g
Pd(OAc)2 0.06 mg 1.2 mg
DIPEA 0.096 g 1.92 mg
MeCN 1 mL 20 mL

Table 2: Heck Coupling Conditions

Mode Temperature Time Scale Isolated Yield
Batch 190 °C 5 minutes 0.5 mmol 89%
Flow 190 °C 30 minutes 10 mmol 91%
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Items 1-10 of 16

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  1. 165034

    80 mL Reaction Vessel

    165034

    The 80 mL reaction vessel has a maximum working volume of 50 mL and miniumum working volume of 15 mL. This vessel can also withstand temperatures up to 200°C with the IR (250°C with fiber optic) and pressure up to 200 psi (250 psi with fiber optic).

  2. 165010

    80 mL Vessel Holder

    165010
    Vessel stand for the 80 mL Discover vessel.
  3. 164755

    Fitting Removal Tool

    164755
    1" (2.54 cm) fitting removal tool.
  4. 80 mL Flow Cell Locking Cover

    80 mL Flow Cell Locking Cover

    542380
    Locking cover assembly for the Discover SP 80 mL flow cell.
  5. Flow Cell Dip Tube

    Flow Cell Dip Tube

    164307
    Dip tube replacement for the 80 mL flow cell.
  6. Flangeless Nut, 1/4-28 x 1/8

    Flangeless Nut, 1/4-28 x 1/8"

    164545
    Replacement long flangeless nut, 1/4-28 x 1/8" for the 10 mL and 80 mL flow cells.
  7. 544610

    10 mL Flow Cell Attenuator

    544610
    10 mL flow cell attenuator for the Discover S-Class and Discover SP. Not compatible with the Discover Legacy.
  8. Tube Fitting, 5/16-24 for 1/8

    Tube Fitting, 5/16-24 for 1/8" Tube

    165180
    Tube fitting, 5/16-24 for 1/8" tube for the 10 mL Discover flow cell.
  9. 165990

    Pressure Tube Fitting with Ferrule, 0.25" Extension

    165990
    Pressure tube fitting with ferrule and 0.25" extended tube for the 10 mL Discover flow cell.
  10. 165995

    Pressure Tube Fitting with Ferrule, 3.65" Extension

    165995
    Pressure tube fitting with ferrule and 3.65" extended tube for the 10 mL Discover flow cell.
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