Microwave Peptide Synthesis

Unmatched Performance - Purity, Efficiency, and Speed

The use of microwave energy has transformed the field of solid phase peptide synthesis. Peptides can now be produced with higher purity, significantly less waste (~10%), and much faster synthesis times (up to 10 times shorter) compared to traditional methods. Nearly 1,000 papers per year are published worldwide on microwave peptide synthesis. Since 2003, CEM has led the way in this field with innovative instrumentation and chemistry advancements.

Related Articles and Case Studies

• New Methodology for Waste Reduction in Peptide Synthesis
• Large Scale Production of Eptifibatide
• Case Study - Scale-Up with Microwave Peptide Synthesis

Complete Automation

Fully Automated Production of GLP-1 Peptides

The Liberty PRO system provides for the complete automation of GLP-1 agonist peptides and other advanced sequences, which simplifies operations while boosting throughput and reliability.

Capable of synthesizing up to 300 mmol of Liraglutide, Semaglutide, and Tirzepatide in less than 30 hours, the system enables rapid, large-scale production without compromising precision. Using 2 equivalents of Fmoc Amino Acid, it achieves exceptionally high purity that meets ANDA standards for GLP-1 peptides. Proven in the production of these high-demand pharmaceuticals, this helps accelerate development and remain competitive.

Scalable Production (Up to 15L reaction vessel)

Seamless Scale-Up from Development to Kilogram Production

The Liberty PRO shares the same chemistry principles as CEM’s Liberty R&D platforms, ensuring direct transferability from discovery to clinical manufacturing.

Its large-capacity reaction vessels, precise reagent metering, and consistent microwave delivery ensure reliable scale-up. This reduces the time needed for technology transfer for pharmaceutical companies and enables CMOs to quickly onboard new client sequences with high confidence.

Develop a synthetic methodology on the R&D scale using Liberty systems and easily reproduce it at production scale with the Liberty PRO. Temperature ramping rates can be programmed to match exactly between the different scales on both systems.

Batch-to-Batch Reproducibility

Quality Assurance

Consistent batch-to-batch reproducibility allows for dependable manufacturing processes and easy batch pooling. Internal temperature monitoring and precise, controllable temperature ramping with dual mode mixing provides consistent peptide quality. This allows for large-scale production from rapid batch production while meeting stringent cGMP requirements.

Lower Cost Per Gram Through Efficient Chemistry & Automation

Profit Optimized

Optimized reagent use, faster complete reactions, and less washing help lower overall manufacturing costs and time.

By producing more peptides per run while reducing waste, Liberty PRO helps manufacturers increase profitability and stay competitive. For CMOs, the lower cost per gram makes it easier to offer attractive prices while maintaining strong operational margins.

cGMP-Ready System with 21 CFR Part 11 Compliance

Meets your Compliance Needs

The Liberty PRO features secure user management, electronic signatures, audit trails, and automated batch documentation to streamline cGMP integration. Its controlled workflows and validated processes lower regulatory risks and ensure consistent results across manufacturing runs. For CMOs producing APIs for multiple clients, the system’s traceability and compliant data handling boost confidence during inspections and client audits.

Instrument regulatory documentation:

• Wetted materials certifications
• Extractables/Leachables Testing
• ATEX analysis report
• Functional and Software Design Specification (FDS/SDS)
• Factory Acceptance Testing (FAT)
• Installation and Operation Qualification (IQ/OQ)

Inert, cGMP Compliant Wetted Materials

Easy Maintenance

Liberty PRO provides highly efficient, automated peptide synthesis with minimal reagent carryover and lower contamination risk. Its no-cross-contamination fluidics, disposable lines, and easy-flush pathways enable QC and manufacturing teams to keep cGMP-compliant cleanliness while maximizing instrument uptime. The system’s robust, closed architecture further improves traceability, repeatability, and confidence in every batch.