Welcome to CEM.com


The Liberty Blue™ Automated Microwave Peptide Synthesizer is the gold standard for peptide synthesis. It features unmatched 4-minute cycle times along with a 90% solvent reduction based on High Efficiency Solid Phase Peptide synthesis (HE-SPPS) developed in 2013. This system is utilized in hundreds of laboratories worldwide and provides unparalleled peptide quality based on its unique methodology and use of microwave energy. The Liberty Blue features the latest in engineering for fluidic deliveries, true internal temperature feedback control, and software control with 21CFR part 11 compliance.


Unique Chemistry

  • 4 min cycle time
  • 90% waste reduction (HE-SPPS)
  • CarboMAX™ coupling chemistry (patented)
  • Microwave deprotection and coupling (patented)


  • Flex-Add™ critical reagent delivery system (patented)
  • True Internal fiber-optic temperature control
  • 0.005 - 5 mmol scale range
  • 27 amino acid positions
  • Integrated Camera
  • High-throughput upgrade options



Phoenix Safety

The fastest peptide synthesizer available.

  • 4 min cycle times (HE-SPPS)
  • Access to peptides in less than a day
  • Optional automated synthesis of up to 24 peptides
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CarboMAX: The best coupling method for peptide synthesis.

  • The fastest and most complete coupling
  • Unmatched low level of epimerization for all 20 amino acids
  • Highest purities with patented microwave deprotection and coupling (US7393920, US7582728, US8058393, CA2471687)
  • Simplify synthesis by eliminating the need for time consuming method screening
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Flex-Add: The best way to deliver critical reagents.

  • Infinitely variable – deliver whatever volume you want (unlike sample loops)
  • No priming ever
  • No washing and less complex than syringe pumps
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Unprecedented 90% solvent reduction.

  • Judicious use of solvents and reagents from optimized washing and synthetic protocols
  • Superior system design minimizes calibration, cleaning, and maintenance needs
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The most advanced software for simple and flexible control.

  • Automated programming of standard and complex peptides (branched, cyclized, disulfide bonding)
  • 21CFR Part 11 compliance including full run history and method reports
  • Integrated real-time camera into microwave cavity



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Branched Peptides

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Cyclized Peptides

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Disulfide Bonding

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Glycopeptides (N/O-linked)

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High Throughput Synthesis

N-Methyl peptides image

N-Methyl Peptides

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Peptide Thioesters

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phosphopeptide image


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November 10, 2015

Prof. Fernando Albericio
University of Barcelona

July 29, 2015

Dr. Hajime Hibino
Peptide Institute

July 7, 2015

Dr. Adel Ahmed
Drexel University

May 12, 2015

Dr. Olga Avrutina
Technische Universität Darmstadt

April 20, 2015

Dr. Patrick C. Reid
PeptiDream Inc.

March 30, 2015

Prof. Hironobu Hojo
Osaka University

June 28, 2015

Dr. Jody Mason
University of Bath

June 4, 2015

Prof. Anna Maria Papini
University of Florence.

May 24, 2015

Dr. Brandon Kier
University of Washington


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