Welcome to CEM.com

Overview

The Liberty Blue™ Automated Microwave Peptide Synthesizer is the gold standard for peptide synthesis. It features unmatched 4-minute cycle times along with a 90% solvent reduction based on High Efficiency Solid Phase Peptide synthesis (HE-SPPS) developed in 2013. This system is utilized in hundreds of laboratories worldwide and provides unparalleled peptide quality based on its unique methodology and use of microwave energy. The Liberty Blue features the latest in engineering for fluidic deliveries, true internal temperature feedback control, and software control with 21 CFR Part 11 compliance.

Awards

2014 R&D 100 Award Winner

Unique Chemistry

  • 4 min cycle time
  • 90% waste reduction (HE-SPPS)
  • CarboMAX™ coupling chemistry (patented)
  • Microwave deprotection and coupling (patented)

Features

  • Flex-Add™ critical reagent delivery system (patented)
  • True Internal fiber-optic temperature control
  • 0.005 - 5 mmol scale range
  • 27 amino acid positions
  • Integrated Camera (optional)
  • High-throughput upgrade options

 
Liberty Blue speed image


Speed

An Incredibly Fast Peptide Synthesizer

  • 4 min cycle times (HE-SPPS)
  • Access to peptides in less than a day
  • Optional automated synthesis of up to 24 peptides
 
Liberty Blue Carbo Max image


CarboMAX

The best coupling method for peptide synthesis

  • The fastest and most complete coupling
  • Unmatched low level of epimerization for all 20 amino acids
  • Highest purities with patented microwave deprotection and coupling (US7393920, US7582728, US8058393, CA2471687)
  • Simplify synthesis by eliminating the need for time consuming method screening

View Application Data
 
Liberty Blue Flex Add image


Flex-Add

The best way to deliver critical reagents

  • Infinitely variable – deliver whatever volume you want (unlike sample loops)
  • No priming ever
  • No washing and less complex than syringe pumps
 
Liberty Blue solvent image


Solvent Reduction

Unprecedented 90% solvent reduction

  • Judicious use of solvents and reagents from optimized washing and synthetic protocols
  • Superior system design minimizes calibration, cleaning, and maintenance needs
 
Liberty Blue software image


Software

The most advanced software for simple and flexible control

  • Automated programming of standard and complex peptides (branched, cyclized, disulfide bonding)
  • 21 CFR Part 11 compliance including full run history and method reports
  • Integrated real-time camera into microwave cavity
 
Liberty Blue Purity image


Purity

We’ve raised the standard for peptide purity

Liberty Blue systems deliver unparalleled peptide quality and synthesis success. From the fundamental principle of using controlled microwave energy to heat the reaction and not the vessel, to the innovative design of hardware, software and speciality chemicals, to the focus on efficient systems for loading, delivery, monitoring and removal, everything contributes to optimal chemistry for the highest purity and yields.

View Published Data
 
liberty blue HT12 applications image


Applications

Synthesize standard and complex peptides.

  • Branched Peptides
  • Cyclized Peptides
  • Disulfide Bonding
  • Glycopeptides (N/O-linked)
  • High Throughput Synthesis
  • N-Methyl Peptides
  • Peptide Thioesters
  • Peptoids
  • Phospho-peptides
  • PNA

View Application Data

 


Testimonials

November 10, 2015

Prof. Fernando Albericio
University of Barcelona

July 29, 2015

Dr. Hajime Hibino
Peptide Institute

July 7, 2015

Dr. Adel Ahmed
Drexel University

May 12, 2015

Dr. Olga Avrutina
Technische Universität Darmstadt

April 20, 2015

Dr. Patrick C. Reid
PeptiDream Inc.

March 30, 2015

Prof. Hironobu Hojo
Osaka University

June 28, 2015

Dr. Jody Mason
University of Bath

June 4, 2015

Prof. Anna Maria Papini
University of Florence.

May 24, 2015

Dr. Brandon Kier
University of Washington


Questions

We’re happy to help.

We are here to help

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