Microwave Peptide Synthesizer
Liberty Blue 2.0

Synthesize peptides more efficiently than ever before.



The Liberty Blue™ 2.0 is the exciting next generation of the best-selling peptide synthesizer in the world. Compared to its predecessor, the Liberty Blue 2.0 features the ability to make cleaner and longer peptides with a new level of robustness. The system features a 4-minute cycle time along with a 90% solvent reduction based on High Efficiency Solid Phase Peptide synthesis (HE-SPPS). The Liberty Blue 2.0 features the latest in engineering for fluidic deliveries, true internal temperature feedback control, and software control with 21 CFR Part 11 compliance

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Unique Chemistry

  • CarboMAX™ coupling chemistry (patented)
  • Microwave deprotection and coupling (patented)
  • Nitrogen Headspace Flushing (patent pending)


  • 4 min cycle time
  • 90% waste reduction (HE-SPPS)
  • Flex-Add™ critical reagent delivery system (patented)
  • True Internal fiber-optic temperature control
  • 0.005 - 5 mmol scale range
  • 27 amino acid positions
  • Integrated RV Camera
  • High-throughput upgrade options (HT4, HT12)

Unmatched Quality

A new level of peptide purity.

The Liberty Blue 2.0 provides the ability to make even higher purity peptides than previously possible with the original Liberty Blue system. This is based on advances in the system fluidics, reaction vessel environment, and chemistry methodology.

  • Optimized microwave chemistry methodology with ProTide resins
  • Cleanest reaction environment with updated headspace flushing technology
  • More direct optimized flow paths
  • Digitally variable N2 control for optimized bubbling, purging, and draining
Length: 89 amino acids
Synthesis Time: 14 hr 43 min.
Waste Generated: 2696 mL
Scale: 0.05 mmol

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The best way to deliver critical reagents.

  • Infinitely variable – deliver whatever volume you want (unlike sample loops)
  • No priming ever
  • No washing and less complex than syringe pumps

High Throughput (HT) Loaders

High Throughput (HT) Loaders

High-throughput peptide synthesis made easy.

  • Automated synthesize of 4 or 12 peptides (individual 20mer’s completed every 1.5 hours)
  • The Liberty Blue 2.0 paired with either the HT4 or the HT12 keeps up with conventional parallel systems

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Flexible, Powerful Software

The newly updated software is both flexible and easy to use, making sure nothing stands between you and your synthesis. Customize methods with unique monomers, orthogonal deprotection, branching, cyclizing, and more. Easily check on reactions on the run screen, where the run can be edited, paused, and resumed at any time.

Method Editor

Easy and Flexible Sequence Programming

The method editor on the Liberty Blue allows full customization of reaction parameters.


Alternate Chemistry and Post-Synthetic Modification

Program Post-Synthesis Modification

Versatile options enabling orthogonal deprotection for modifications like branching and cyclization.


Calculator for Reagents

Full Suite of Calculator Tools

Convenient calculators provide the reagents and amounts for a run.


Edit on the Run

Pause, Edit, Monitor at any Step

Easily pause, edit, and monitor reactions from the run screen.



Synthesize standard and complex peptides.

The Liberty 2.0 series, like preceding models, utilizes CEM’s High-Efficiency Solid Phase Peptide Synthesis (HE-SPPS) and CarboMAX coupling methodologies.

Branched Peptides
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Cyclized Peptides
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Disulfide Bonding
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Glycopeptides (N/O-linked)
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High Throughput Synthesis
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N-Methyl Peptides
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Accessories and Related Products

HT 4


The HT4 automates peptide synthesis with the ability to queue up to 4 peptides. New reactions can be programmed at any time, even while another sample is running.

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HT 4


The HT12 option for the Liberty Blue and Liberty Prime provides automation for up to 12 peptides. New peptides can be added and programmed at any time, even while another sample is running.

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The Razor from CEM provides high temperature, rapid cleavage on up to 12 samples simultaneously. Finish cleavage in just 30 minutes with the Razor.

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The Prodigy Preparative HPLC is a purification system optimized for use with biomolecules like peptides and proteins. The fully integrated temperature control for the column and mobile phase is a powerful tool, especially for difficult or hydrophobic samples

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