Microwave chemistry has long been known to accelerate chemical transformations and provide a simple means to access more rigorous reaction conditions. Flow chemistry has demonstrated similar benefits, with the added bonus of being able to increase the reaction scale simply by prolonging the reaction. The combination of the two technologies opens the door to a quick optimization and easy scale-up of virtually unlimited types of chemical transformations. The Discover® SP System provides the means to perform both types of reactions simultaneously or sequentially within the same system. Use of microwave heating allowed access to a temperature of 190 °C, well above the boiling point of acetonitrile. This increased temperature resulted in a pressure of nearly 200 psi during the batch reaction. Despite these forcing conditions, the reaction proved suitable for synthesis in flow, providing a modest increase in yield with a 20-fold increase in scale.

Discover 10-mL and 80-mL Flow Cells

10-mL and 80-mL Flow Cells

Explore continuous flow chemistry in the microwave using two standard flow cell sizes.

MAX. PRESSURE: 18 bar (250 psi)

View Flow TechNote

Table 1: Heck Reagents Required

Reagent Batch Flow
Iodobenzene 0.101 g 2.02 g
Butyl acrylate 0.127 g 2.54 g
Pd(OAc)2 0.06 mg 1.2 mg
DIPEA 0.096 g 1.92 mg
MeCN 1 mL 20 mL

Table 2: Heck Coupling Conditions

Mode Temperature Time Scale Isolated Yield
Batch 190 °C 5 minutes 0.5 mmol 89%
Flow 190 °C 30 minutes 10 mmol 91%

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16 Item(s)

  1. 1/8" Yellow Ferrule
    SKU: 164315

    The 1/8" Yellow Ferrule is used to secure 1/8" OD tubing. Learn More
  2. Rare Earth Stir Bar
    SKU: 164810

    9 mm x 15 mm stir bar, used with all 35 and 100 mL reaction vessel accessories. Learn More
  3. 80 mL Reaction Vessel
    SKU: 165034

    The 80 mL reaction vessel has a maximum working volume of 50 mL and miniumum working volume of 15 mL. This vessel can also withstand temperatures up to 200°C with the IR (250°C with fiber optic) and pressure up to 200 psi (250 psi with fiber optic).

    Learn More
  4. 80 mL Vessel Holder
    SKU: 165010

    Vessel stand for the 80 mL Discover vessel. Learn More
  5. Fitting Removal Tool
    SKU: 164755

    1" (2.54 cm) fitting removal tool. Learn More
  6. Locking cover assembly for the Discover SP 80 mL flow cell. Learn More
  7. Flow Cell Dip Tube
    SKU: 164307

    Dip tube replacement for the 80 mL flow cell. Learn More
  8. Replacement long flangeless nut, 1/4-28 x 1/8" for the 10 mL and 80 mL flow cells. Learn More
  9. 10 mL flow cell attenuator for the Discover S-Class and Discover SP. Not compatible with the Discover Legacy. Learn More
  10. Tube fitting, 5/16-24 for 1/8" tube for the 10 mL Discover flow cell. Learn More
  11. Pressure tube fitting with ferrule and 0.25" extended tube for the 10 mL Discover flow cell. Learn More
  12. Pressure tube fitting with ferrule and 3.65" extended tube for the 10 mL Discover flow cell. Learn More
  13. PFA Tubing, 1/8" OD 1/16" ID Learn More
  14. Discover 80 mL attenuator vessel lifter cup. Learn More
  15. Multibit Reversible Screwdriver Learn More
  16. Phillips head screwdriver Learn More

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16 Item(s)