Wednesday Webinars on Separation Solutions




Summary

Sample preparation and chromatographic separation, by gas or liquid chromatography, are the backbone of many industries. Achieving the balance of timely and efficient sample prep with affordable analysis tools is something many labs struggle with. In this webinar series, hear from industry and academic chemists that have optimized their analytical protocol, on a wide variety of samples, by implementing sample prep and analysis solutions from CEM and Lucidity Systems.

What You’ll Learn

  • Improve sample prep and analysis of a broad range of samples
  • Affordable separation solutions for any lab
  • Advances in gas chromatography systems and their applicability in petrochemical applications
  • Green mini gas chromatography (GC-FID) solutions for essential oils, drugs, and fuels
  • Use of liquid chromatography (LC-UV) for pharmaceutical analyses
  • Application and training of researchers to use the miniGC

Who Should Attend

  • Lab Managers
  • Professors
  • Analytical Chemists

Equipment Used

Part 1

Simple and Efficient Solutions for Sample Preparation and Analysis

Date: Wednesday, March 23, 2022
Time: 11:00 AM – 12:00 PM
Alicia Douglas Stell, Ph.D.
Product Manager, Organic Solutions Division
CEM Corporation
 

To achieve efficient analysis for analytes in solid matrices an efficient extraction is first necessary. CEM offers solvent extraction solutions that produce excellent recoveries extracted in less than 10 minutes in one simple automated process. CEM’s extractions solutions can be paired with Lucidity analysis systems, the miniGC and miniLC. The miniGC, a GC-FID, and the mini-LC, an LC-UV, offer ease of use with a small footprint. The systems are so simple that the operator does not need to be a trained chemist, and the small footprints allows the movement of the systems for point of need analysis. Spanning numerous applications in many markets, including food and environmental, CEM sample preparation solutions combined with Lucidity analysis systems allows for accessibility of this type of work to those whom previously considered it impossible. Thus, CEM and Lucidity systems are an excellent option for laboratories seeking a simple solution for extraction and analysis.

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Part 2

Detection and Quantification of THC Isomers in Cannabis Infused Edibles

Date: Wednesday, March 23, 2022
Time: 3:00 – 4:00 PM
Todd Griffin
CEO and Chief Scientist
Griffin and Griffin Analytical Associates
 

The popularity of cannabis infused edibles continues to increase due to state medical and recreational cannabis programs. The 2018 Farm Bill has also led to the introduction of hemp infused consumer products. Recently, hemp derived THC isomers, such as delta-8 THC, have been infused into a wide variety of edibles. The complex nature of edible matrices, and chemical similarity in the THC isomers, presents challenges for labs to accurately detect and quantify these cannabinoids. There is a need for cost effective and reliable sample preparation and analysis techniques. Traditional sample preparation techniques, like QuEChERS, are slow and complex. A novel automated solvent extraction method has been used to prepare the edibles infused with THC isomers and a miniature high pressure liquid chromatography system is used to analyze the samples. This presentation will present the automated sample preparation technique and compare results with QuEChERS method. The HPLC method will be presented along with results from the miniature HPLC.

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Part 3

Recent Developments and Innovations in Gas Chromatographic Hardware

Date: Wednesday, March 30, 2022
Time: 11:00 AM – 12:00 PM
Ronda Gras, PhD
Research Scientist of analytical Science, Core R&D
Dow Chemical Company
 

Gas chromatography (GC) is considered a mature analytical technology with many critical industrial applications. Despite its maturity, the role of GC has not been diminished. Instead, its role continues to gain influence. Innovations that aid in widening the use of contemporary GC include: maintaining gas chromatographic performance without compromising affordability, enhanced data reliability between analysts, and precise digital pneumatic controls. In this talk, Ronda Gras will discuss advancements in gas chromatography (GC) with novel system improvements that enable ease of use, even when operated by inexperienced operators. Since ease of use means nothing if the data is not meaningful, Dr. Gras will review applications in the petrochemical and chemical industries and determine if data is comparable to larger GC systems

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Part 4

Making Gas Chromatography “Greener” Using Common Sense Optimizations, Simplified Methods and Miniaturized Instrumentation

Date: Wednesday, March 30, 2022
Time: 3:00 – 4:00 PM
Nicholas Snow, PhD
Professor, Analytical Chemistry, Separation Science Director
Seton Hall University
 

Of all chromatographic techniques, GC still offers the most powerful combination of speed, separation efficiency and ease of use. However, when developing and optimizing methods, it is well known that one can usually have two of these as priorities for the final method, but it is difficult to have all three. In addition, we are now interested in making our methods and analyses “greener” using the Principles of Green Chemistry along with miniaturized instrumentation, with smaller footprint and lower power consumption. Using applications from a variety of areas, including analysis of essential oils, drugs, and fuels, we will discuss method optimization in GC in light of common method development goals and the green chemistry principles. We will see that examining several of the common choices that we make in capillary GC, often based on assumptions from packed column days, such as carrier gas, sample solvent and extraction or injection technique can both improve a method and make it greener at the same time. Our examples will also highlight the use of a miniaturized and simplified gas chromatograph and a gas generator that provides all three gases for GC-FID analysis, reducing power consumption and bench space.

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Part 5

Utilizing Compact, Integrated Chromatographic Instrumentation for Pharmaceutical Analysis

Date: Wednesday, April 6, 2022
Time: 11:00 AM – 12:00 PM
Jim Grinias PhD
Associate Professor, Department of Chemistry & Biochemistry
Rowan University
 

In the realm of quality assurance and quality control within the pharmaceutical industry, reliable and robust analytical methodology is of utmost importance. Many pharmaceutical analysis techniques rely upon chemical separations, especially the use of LC-UV for drug substance and impurity assays. In this presentation, considerations for method development, method validation, and system suitability will be explored in the context of small molecule pharmaceutical analysis, especially common over-the-counter analgesic compounds with published pharmacopeial monograph methods. Considerations for acceptable changes that can be made to methods within pharmacopeial guidelines will also be discussed, including potential advantages and disadvantages that may be observed for various changes. Finally, multiple examples of analgesic drug analysis performed using the new miniLC platform will be demonstrated.

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Part 6

Training the next generation of chromatographers using Lucidity miniGC in the research and teaching laboratories

Date: Wednesday, April 6, 2022
Time: 3:00 PM – 4:00 PM
Emanuela Gionfriddo, PhD
Assistant Professor, Department of Chemistry & Biochemistry
The University of Toledo
 

This webinar will describe applications of the Lucidity miniGC for research and teaching purposes. Research projects describing analysis of plant volatiles and determination of residual solvents in recycled acetone will be discussed, as well various strategies to implement the use of the miniGC in the analytical chemistry laboratories and provide the students with hands-on experience on a user-friendly chromatographic system.

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