The Liberty Lite™ Upgrade converts a Discover to an automated microwave peptide synthesizer designed for Fmoc solid phase peptide synthesis. The system is capable of automated synthesis of a single peptide. The standard synthesis scale is 0.005 - 5 mmol using a 30mL reaction vessel. The Liberty Blue™ uses a Discover single mode microwave reactor that provides for self-tuning with a continuous power delivery from 0-300 Watts in 1-Watt increments. The system contains 20 ports standard for amino acid, and 4 external ports for other reagents. All reagent deliveries are controlled by nitrogen pressure.
Synthesis Scale 0.005 – 5 mmol Reaction Vessel Sizes 30 and 125 mL standard Chemistry Fmoc only Activation Method In situ, standard activators Amino Acid Reagents 20 External Bottle Positions 4 plus Temperature Measurement In situ Fiber-optic Fluid Measurement Flex-Add - amino acids, activator, activator base Timed delivery – main wash, deprotection Agitation Programmable inert gas bubbling Waste Container 1 L reservoir with overflow detection Controller Laptop with wireless option standard Reports Printable .pdf file for each method created. Log created during each run of every step performed Power 120V/60Hz or 240V/50Hz Dimensions20”W x 18”D x 30”H(51 cm x 46 cm x 76 cm) LicenseThe purchase of this instrument includes a grant of a limited, non-transferrable license to use this instrument for microwave peptide synthesis using microwave energy for both the coupling and deprotection steps. Patents US7393920; US7582728; US8058393; EP1491552; JP4773695, with additional worldwide patents pending