Liberty PRIME Proves Successful in New Research
New peptide synthesis research using the Liberty PRIME peptide synthesizer was presented on Aprill 22nd and 24th in a series of seminars in Tokyo and Osaka, Japan. The research showed the highly efficient synthesis of a wide range of peptides including cyclotides, N-methyl peptides, and glucagon-like peptides. The unique methodology and instrument design of the Liberty PRIME allows for major synthesis improvements over CEM's best selling Liberty Blue line of peptide synthesizers.
Figure 1: UPLC Chromatogram of ABC 20mer Synthesized on the Liberty Blue
Figure 2: UPLC Chromatogram of ABC 20mer Synthesized on the Liberty PRIME
Table 1: Synthesis of VYWTSPFMKLIHEQCNRADG-NH2 (ABC 20mer) on the Liberty Blue and Liberty PRIME
| Instrument | Crude Purity | Synthesis Time | Wash (DMF) Requirement | Total Waste |
|---|---|---|---|---|
| Liberty Blue | 77% | 93 min | 187 mL | 340 mL |
| Liberty PRIME | 83% | 46 min | 88 mL | 168 mL |